The Role of Long Non-coding RNAs in Immunotherapy Resistance

The Role of Long Non-coding RNAs in Immunotherapy Resistance

Blog Article

T-cell-based immunotherapies, particularly immune checkpoint inhibitors, are promising treatments for various cancers.However, a large subset of patients develop primary or secondary resistance upon treatment.Although the detailed mechanisms remain unclear, immune escape via alterations in both cancer and tumor microenvironment has been identified Vitamin E as critical causes of immune resistance.

Moreover, some long non-coding RNAs (lncRNAs), named as immune-related lncRNAs, have been recognized as regulators of immune cell-specific gene expression that mediate immune processes.These immune-related lncRNAs may play a vital role in immunotherapy resistance.Herein, we summarize current immune-related lncRNAs and their underlying roles in immune resistance to provide strategies for future research Culottes and therapeutic alternatives to overcome immunotherapy resistance.